.

.
marylin monroe
Showing posts with label pizza. Show all posts
Showing posts with label pizza. Show all posts

Planning to Have a Pizza? Preload w/ Navy Beans, Chickpea or Lentils to Ameliorate Your Glucose Response. Plus: Are the Changes Even Physiologically Relevant?

I am pretty sure that putting means onto your pizza will also work, but probably only due to replacing unhealthier stuff ;-)
It sounds funny, but eating a 188g of canned, well-chewed navy beans, 62.5g whole navy bean powder, 184g of whole canned green or their pureed counter-part, or simply chewing down 48g of Eston lentil powder or 148.8g of canned or pureed chickpeas will ameliorate the glucose response to a standardized pizza meal.

Speaking of which: The nutritional composition of the pulse treatments and control is listed in Table 1. All treatments and control were of similar available carbohydrate content (38·8 g), with 25 g from the test ingredient (pulses or whole-wheat flour) and 13·8 g from the tomato sauce.
It may also be that beans modulate your gut microbiome 

Fiber for Female Fat Loss

Sweeteners & Your Gut

Foods, Not Ma- cros for the Gut

Lactulose For Gut & Health

Probiotics Don't Cut Body Fat

The Macrobiotic MaPi2.0 Diet
The pulse treatments and control were prepared the day before each session, transferred to airtight containers, combined with water to reach a final weight of 405·0 g, and sealed in airtight containers for overnight storage in an experimental fridge.
Table 1: Nutritional composition of the "preloads" (Anderson. 2014)
To prepare the whole-pulse treatments, canned navy beans (Expt 1), lentils (Expt 2) and chickpeas (Expt 3) were poured into a strainer, washed thoroughly under running water for 30 s and drained well. Pulses were then combined with filtered water while the tomato sauce ingredients were cooked in a non-sticky pan on medium heat (3 min).
But beans are bad for my health, aren't they? From a psychological perspective, you may be right. In view of the fact that people really feel sick, when they've read about the (non-existent) ill health of effects of certain foods on the Internet. Some of you may actually become sick ;-)

Mechanism by which beans reduce your hyperlipidemia, diabetes and cancer risk (Hayat. 2014).
Aside from the fact that starting eating tons of beans from one day to the other may overload your digestive tract and make you "socially incompatible" (due to flatulence), the overwhelming majority of scientific studies indicates that an increased consumption of Beans (Phaseolus vulgaris L.) will not just improve your supply of nutrients such as multifaceted carbohydrates, proteins, dietary fiber, minerals, and vitamins, but also exert direct health benefits due to their rich variety of polyphenolic compounds with (Hayat. 2014). These benefits range from a general improvement of your antioxidant defense system over reductions in cardiovascular disease risk and improvements of your lipid and glucose metabolism to a reduced cancer risk.
In order to make them palatable, the pulses were mixed with tomato sauce, garlic and herbs, dried basil leaves, ground black pepper, garlic powder, dried parsley flakes, and the typical American way with added sugar (1.2 ml).
The subjects, young men, aged 18-25 years old with a normal BMI reported at the lab following a 10–12 h overnight fast, participants were instructed to consume a standardised breakfast (1422.6 kJ) in the morning within 15 min and arrive at the laboratory 4 h later.
"The standardized breakfast was provided to them in advance and consisted of 26 g of Honey Nut Cheerios cereal (General Mills), 250 ml of Beatrice 2 % milk (Parmalat Canada) and 250 ml of Tropicana orange juice (Tropicana Products, Inc.). In addition, 500 ml of bottled water (Canadian Springs) were included, and participants were required to finish the bottle by 1 h before the session start time." (Anderson. 2014)
Upon arrival, participants were asked to complete a Sleep Habits and Stress Factors Questionnaire and an Activity Questionnaire. If they reported significant deviations from their usual patterns, they were asked to reschedule. Baseline blood samples were obtained by finger prick by a Monojector Lancet Device (Sherwood Medical), and the blood glucose (BG) concentrations were measured by using a glucose meter (Accu-Chek Compact Plus Glucose Monitor; Roche Diagnostics Canada).

What exactly did the scientists do with the "preloads"?

After taking baseline measurements for BG, participants were given 15 min to consume either one of the treatments or control provided to them in random order with 250 ml of filtered water. BG concentration was measured at 15, 30, 45, 60, 90 and 120 min. At 120 min, participants were asked to consume a fixed-size pizza meal (50·2 kJ/kg body weight, McCain Deep ‘N Delicious; McCain Foods Limited) with 500 ml of filtered water (which could be consumed ad libitum) within 20min in order to measure post-second-meal glycaemic response without the variation introduced by ad libitum food intake. The pizzas averaged 7·6 g protein, 4·9 g fat, 29·3 g carbohydrate and 818·6 kJ/100 g. Each cooked pizza (8 min at 227 8C and cut in quarters) was weighed before serving. Following the pizza meal, BG concentration was measured repeatedly at 140, 155, 170, 185 and 200 min.
Figure 1: Effect of the treatments on absolute blood glucose concentration over time. (A) Expt 1, (B) Expt 2 and (C) Expt 3. Values are means (n 17 in Expt 1, n 12 in Expt 2 and n 12 in Expt 3), with their standard errors represented by vertical bars (Anderson. 2014).
As you can see in Figure 1, the improvements were not exactly earth-shattering. Against that background it is questionable, whether the overall lower glycaemic response will be of practical relevance.
Navy beans are also a good source of fermentable starches (10g per 1/2 cup) and could thus have longer lasting beneficial effects by eventually ramping up your short-chain fatty acid production and thus promoting longterm fat loss, improved gut health and cancer protection | learn more about these and other benefits of fermentable starches!
So what's the important finding, then? In view of the modest reductions in glycemia, the most important finding of the study probably isn't the overall reduction in glycemia, which has been observed in previous studies, already. Rather than that, it is the fact that the pureed and, even more surprisingly, the powdered premeals had the same effect as the fresh whole beans, lentils and chickpea.

Or, as the scientists write the fact that "commercial processing of pulses to a powder form does not alter their low glycaemic characteristics" (Anderson. 2014). Accordingly, pulse powders can be used as "value-added ingredients in home cooking and functional foods to improve postprandial glycaemic control" (Anderson. 2014) - more specifically this could be a way to add pulses to convenience foods and thus have those individuals who normally avoid them due to taste or perceived inconvenience benefit from the improved glycemia | Comment on FB!
References:
  • Anderson, G. Harvey, et al. "The acute effect of commercially available pulse powders on postprandial glycaemic response in healthy young men." British Journal of Nutrition (2014): 1-8. 
  • Hayat, Imran, et al. "Nutritional and health perspectives of beans (Phaseolus vulgaris L.): An Overview." Critical reviews in food science and nutrition 54.5 (2014): 580-592.

Pre-Meal Protein Ingestion to Improve Glucose Tolerance: Insulin, GIP, GLP-1 - That's the Whey(!) it Works! Plus: Even Pure Glucose Can "Improve Your Insulin Tolerance"

Can a whey protein appetizer really undo the damage of greasy fast food? Probably not, but it's still interesting to see how it affects the postprandial glycemia.
Insulin resistance is the #1 contributing factor to the obesity epidemic and despite the fact the solution is already out there (read more about the necessary lifestyle modifications), it probably won't hurt to know if something as simple as having a high protein "appetizer" before a junky meal could improve blood glucose management even further, right? "Right, 'cause protein is always, good!" Ah, no... I guess the answer is a little more complex than that... Nevertheless, I still suspect that the results, Tina Akhavan and her colleagues from the University of Toronto present in their soon-to-be-published paper in the Journal of Nutritional Biochemistry will be of interest to you.

The study results are interesting, to say the least...

... and that's not despite but rather because the researchers did not use the usual subjects (rodents, obese individuals or elderly people), but young men (aged 18-29) with a BMI of 18.5-29.4 kg/m². In a randomized cross over design (cross over means that every subject got each treatment - obviously in seperate testing sessions), the subjects drank either...
  • 300ml of a 10g or 20g whey protein solution, 
  • 300ml of a 10g or 20g glucose solution, or
  • 300ml of flavored zero calorie water 
The test drinks were consumed four hours after a standardized (junk = Honey Nut Cheerios + Skim Milk + Orange Juice) "breakfast". 30 min later the subjects were served even more junk in form of a *yummy* frozen Pizza from McCain Foods Ltd.

"Cereals", skim milk, pizza... whey alone won't help to counter that

The Pizza had been prepared "according to manufacturer‘s directions". This means that the reduction in glycemia the scientists observed in response to the protein preload were not because the pizza was still frozen... ok, before I produce even more nonsense, let's take a look at what the whey protein and glucose pre-loads did to the subjects blood glucose responses, right?
Figure 1: Glucose and insulin levels after pre-load and after meal (mean of 30-230min); all values expressed relative to water control, i.e. +85% would mean "85% higher than during control trial" (Akhavan. 2013)
If that's not your first visit to the SuppVersity, I probably won't have to explain the mechanism by which the pre-ingestion of whey (and glucose) reduces the Pizza-induced glycemia - do I? Well, I guess I better repeat it briefly:
  1. The ingestion of the whey protein triggers a significant increase in insulin - 127% for the 10g and 191% for the 20g dosage.
  2. Contrary to the glucose infusion there is no exogenous glucose that could lead to a rapid elevation of blood glucose (cf. figure 1, left → pre-values); the minimal increase you see is produced by gluconeogenesis in the liver.
  3. With the elevated insulin levels, the mean glucose levels in the postprandial phase (30min-230min after the pizza ingestion) is lower with both the glucose and whey preload. The effect is however more pronounced with whey than with glucose. The reason should be obvious: The overall amount of glucose that's got to be stored away is lower.
I know it sounds counter-intuitive, but aside from (2) the mechanism is absolutely identical for the glucose trial - with the insulin already being around low (10g) glucose preload can actually lead to lower postprandial glucose levels than the water control (this is probably only true for healthy individuals).

Insulin? Is that all, or is there more to it?

Now that we have gotten the fundamental mechanism by the means of which "glucose-" and "whey-preloading" before eating pizza can ameliorate the blood glucose surge after the meal, let's take a look at the auxiliary data.
Figure 2: GLP, GIP, PYY, CCK and Ghrelin levels before eating the pizza; all values expressed relative to water control, i.e. +85% would mean "85% higher than during control trial" (Akhavan. 2013)
As the data in figure 2 tells you the increased insulin release was brought about and accompanied by profound increases in the production of the satiety hormones GLP-1 and CCK, as well as the "insulin trigger" GIP (all these changes occured in the pre-meal = pre-pizza phase, only). Ghrelin and PYY, which play an even more important role in the regulatory process that's supposed to control our energy intake, did not show significant treatment dependent differences, though.
What's the practical relevance of these findings? Honestly, I am not sure how relevant the findings from the study at hand actually are. I mean, from a "do this" or "don't do this" point of view - not from a "understanding how things work" perspective.

SuppVersity Suggested Read: "The Satiating Truth About Proteins and Why High Protein and Low Amounts of Low GI Carbs May Not Mix As Well As Most People Think" | read more
For those who would benefit most from reductions in postprandial glycemia, i.e. the obese type II diabetic, it is questionable whether (a) the mean 7% decrease is actually making a difference and whether it would (b) even occur in someone who is having a hard time producing enough insulin to have his / her body react to it.

For the lean individual, on the other hand, the 7% reduction in gylcemia probably doesn't matter at all and the insulin spike before the onslaught of a the "perfect storm" of carbs and fats from a greasy frozen pizza could (worst case scenario) increase the chance of fat storage - I mean the glucose can go to the muscle (learn more), the fat, on the other hand must end up in your adipose organ.

I would thus strongly advice everyone to stick to my "get 30g of quality protein with every meal" recommendation, instead of turning it into a "get 30g of protein before every meal". Aside from the questionable benefits of having the protein before your meal, having it with / as part of your mwal will also direct you away from pizza and towards healthier food choices. After all, you will be hard pressed to find a pizza with 30g+ of protein in it... and I bet the novel "pizza on a stick" I told you about on Facebook, recently, probably doesn't qualify either ;-)
References:
  • Akhavan T et al. Mechanism Of Action Of Pre-Meal Consumption Of Whey Protein On
    Glycemic Control In Young Adults. The Journal of Nutritional Biochemistry. October 2013 [accepted manuscript]