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marylin monroe
Showing posts with label hangover. Show all posts
Showing posts with label hangover. Show all posts

Exercise Round-Up: HIIT Prevents Angina; Stretching Reduces IGF-1 & Strength Gains; Cardio + Weights Lower TNF-Alpha; Protein Doesn't Works W/ Glucose Depletion; Polarization More Effective Than Threshold Training

That's (hopefully) not the way you want to "kick off" your year 2013, is it? So keep the booze at bay and party away, tonight ;-)
There are three things of which I would hope that they are on the top ranks in the things you are planning to do in 2013. And aside from proposing to your girlfriend, becoming a parent, graduating from whatever you are currently studying and keeping or, in the unfortunate case you don't have one, getting a job no other goals should be ranked in this must to in 2013 category: Work out, eat health and sleep deep and sufficiently. Against that background today's exercise round-up, which comprises all the few newsworthy papers that have been published during or shortly before the holiday season can actually be regarded as a means of orientation as far as practical realization of your best intentions for 2013 are concerned.



  • HIIT in the evening will keeps the heart attack away (Morikowa. 2012) -- Having a mild angina (coronary spasm was documented and no severe organic lesions were found) is not just no excuse for not working out, the 26 patients in a recent study that was conducted by a team of researchers from Kashiwara City, Japan, clearly shows that the number of spasms (=perceived heart attacks) was reduced from 2 to ZERO (average numbers) per 5 days in the men and women who performed an aerobic interval exercise training in the afternoon.

    Figure 1: Selected significantly improved health markers before and after the 3x workout short-term intervention involving 19 male and 7 suffering from angina (Morikawa. 2012)
    The protocol was performed on three consecutive days. After warming up thoroughly (10min), all subjects performed four sets of 3 min intervals at 75-85% of their heart rate reserve. The work to rest ratio was 1:1. In other words each of the intervals was followed by a phase of 3 minutes of active recovery. The whole session was concluded by a 5-10 minutes cool down.

    In conjunction with the initially mentioned benefits in terms of the recurrence of angina attacks the data in figure 1 should actually suffice to motivate you and lazy relatives to invest this small amount of time into the length and quality of your life- don't you think so?
  • Figure 2: The group of recreational trained young men (~29 years) that did no stretching at all had slightly, but significantly elevated IGF-1 levels (µg/L) after the workout (Borges. 2012).
    Stretching blunts acute IGF-1 response and 10 week strength gains (8RM test) (Borges. 2012) -- Now, hormonal responses to exercise are certainly not everything, the fact that the non-stretchers (OST) did yet also gain significantly more strength on the bench (19% vs. 7% and 5% in the static stretching during warm-up (SBST) and the stretching before each set (SDST) groups, respectively), the leg press, leg extensions and leg curls should yet call your attention, Mr. and Mrs. "I am so freaking professional that I stretch in between every set" maniacs - after 10 weeks of training the guy next to you who sticks to a handful of warm-up sets for injury prevention is going to outperform you.

    Remember this is not about not warming up and making sure that you don't hurt yourself, it's just even more more evidence that the die-hard belief that static stretches are beneficial (which was btw. also the research hypothesis of the Portuguese and Brazilian scientists) is dated text book knowledge.
  • Again: Not strength or, but strength and aerobics is the way to go (Ho. 2012) -- While the medical establishment is still reluctant to accept the notion that strength and aerobic training must go hand in hand and many muscle heads still plead, they would lose muscle or hamper their gains, when they hopped onto a treadmill from time to time. The evidence is clear: The advantages are simply non-negligible - for the gymbro trying to look muscular (which requires a low body fat percentage if you don't want to look simply ludicrous), and the average Australian (pre-)obese in a recently published study by Ho, Dhaliwal, Hills, and Pal who found that ...
    "Twelve weeks of moderate-intensity aerobic, resistance, but mainly combination exercise training decreased TNF-α in overweight and obese individuals compared to no exercise. Therefore, combination exercise training may be physiologically relevant in decreasing the risk of developing chronic diseases." (Ho. 2012)
    The exercise interventions were either 30 min of aerobic exercise on a treadmill (60 % heart rate reserve; HRR estimated using the Karvonen equation: 220 - age - resting heart rate), 30 min of resistance exercise (four sets of 8–12 repetitions at 10-RMlevel of leg press, leg curl, leg extension, bench press, and rear deltoid row, with each set completed in approximately 30 s with 1-min rest) or a combination of 15 min of aerobic exercise and 15 min of resistance exercise (two sets of the above exercises).
    Figure 3: The combined training did not only result in a maximal suppression of TNF-alpha, the latter was also highly correlated with the reduction in body fat (esp. in the belly area; cf. Ho. 2012)
    "Starting workload levels for each piece of equipment were tested by participants and if more than 10 repetitions were achieved, the weight was increased and after a short rest participants tried again. Likewise, if less than eight repetitions were achieved, the weight was decreased and after a short rest participants tried again. Participants reported to the Curtin Fitness Centre 3 days a week to complete the required exercise and either exercised at home the other 2 days or at the fitness center.

    If exercises were completed at home, dumbbells (adjustable weight 1.5–10.5 kg) were provided for resistance exercises (three sets of 10 repetitions for biceps curls, lunges, dumbbell raise, calf lift, and triceps extension for resistance group while the combination group did two sets of biceps curls and lunges and one set for dumbbell raise, calf lift, and triceps extension; back extension, push ups, and sit ups exercises were also included). Treadmills were equipped with heart rate sensors and participants were instructed to increase weight loads by 2.5-kg increments when they could complete more than 12 repetitions." (Ho. 2012)
    Maybe not the perfect program for you, but I bet you know someone who "wants" to make room for 30 min of exercise in 2013, don't you? Ah,... don't tell them that 67-74% compliance was enough to elicit a 30%+ decrease in TNF-alpha and finally allow the participants to drop body fat, though ;-)
  • You can have your peri-workout protein even if you want to exploit the AMPK & PGC-1 bonus of training glycogen depleted (Taylor. 2012) -- Actually I have discussed that in the Intermittent Thoughts more than a year ago, but since the debate just goes on forever, I thought it may be worth posting the results of a recent study pertaining to the issue of peri-workout protein ingestion and its purported (yet non-existent!) negative side effects on the beneficial AMPK response to glycogen depleting exercises (note: that's not the AMPK that's increased in your brain, when you starve yourself for longer time periods, the "bad" one that will make you ravenously hungry, induce overeating and shut down your metabolism).
    As long as you remain glycogen depleted protein has no effect on the beneficial part of the exercise induced AMPK expression (read more)
    "After performing a glycogen-depleting protocol the evening before, the subsequent morning ten active men performed 45 min steady-state cycling at 50 % of peak power output (PPO) followed by an exercise capacity test (1-min intervals at 80 % PPO interspersed with 1-min periods at 40 % PPO).

    In a repeated measures design, subjects consumed 20 g of a casein hydrolysate solution (PRO) 45 min before exercise, 10 g during and a further 20 g immediately post-exercise, or an equivalent volume of a non-calorie taste matched placebo (PLA)." (Taylor. 2012)
    In view of the fact that the post-exercise muscle glycogen was not different between the protein supplementation and the "on empty" trial, it is not exactly surprising that the p-AMPK levels increased threefold and the PGC-1mRNA increased sixfold in the 3h after the workout. And even the blunted increase in eEF2 activation is probably only a sign that the muscle started taking up protein right away and thus did not have ask for more after the workout - That said,Taylor et al. are right to point out that
    "athletes who deliberately incorporate training phases with reduced muscle glycogen into their training programmes may consume protein before, during and after exercise without negating signalling through the AMPK cascade." (Taylor. 2012)
    Ah, don't overlook the words "training phases" - remember what I wrote about training glycogen depleted in the context of the PGC-1 a-4 post and doing cardio before a workout? It's an intensity technique and not a necessity for everyone on every training day in 2013. Plus, glycogen depletion does require repletion! Running around 24/7/365 is not an option for 2013.
  • Aside "polarization" your cycling performance can also benefit from baking soda & beta alanine (read more)
    Polarize your training and optimize your gains (Neall. 2012) -- What makes HIIT so effective? The cyclicity of high and low intensity, right! It's the same cycle of ups and downs you find everywhere in nature. Against that background it should actually not surprise you that Neal et al. have now found male cyclist record greater training improvements on a polarised model exercise regimen (6.4/hrs per week; 80%, 0%, 20% of training time in low, moderate and high intensity zones) than on a threshold model (7.5hrs per week; 57%, 43%, 0% training intensity distribution).

    According to the researchers from the University of Stirling, both groups recorded performance improvements, yet those in the group that followed the polarized regimen saw 5% greater increases in peak power output, 7% greater increases in lactate threshold, and 48% greater increases in high-intensity exercise capacity.



Thats it for today and in fact for the year 2012. The last one of 365 new posts here at the SuppVersity and probably twice or thrice as many on the SuppVersity Facebook Wall (it would be ~5-6x more on Facebook, if I had started posting short news on Facebook in January already)... Apropos, if you want some additional news before the turn of the year you should make sure to visit www.facebook.com/SuppVersity, today, to read and learn more about.
  • A brief history of anti-hangover cures: The ancient Assyrians swore by Ground birds' beaks and myrrh. Raw eel and bitter almonds is a recipe from Europe that was popular during the Middle Ages. The Mongolians were more into  sheep's eyes, while the Chinese must have listened to Thursday's installment of On Short Notice and went with green tea. Us Germans like it traditional (not me though) and eat "Tom's breakfast" (Katerfrühstück), a postbinge breakfast with Bismark Herring, pickles, rollmops and/or sauerkraut (this stuff does work, by the way, 'cause it helps replenish the lost electrolytes).
    Harvard Health Letters headline: "The new medicine: muscle strength. It's not just for bodybuilders. Strength training is critical for all of us." (read more)
  • Creatine reduces total antioxidant defenses? Scientists confirm for the 1012532x that creatine works and to make sure somebody even reads their study they overemphasis an increase in uric acid and decreases in TAS in the creatine supplementation group - a reason for concern? (read more)
  • Case report: Type I diabetes remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus. (read more)
  • Got Acne? Insulin resistance makes men break out. You better don't rely on fasted values, but get an OGGT ASAP(!) cause it turned out to be the most accurate independent predictor of acne at multivariate analysis. (read more)
I guess the one thing that remains to be said now is:  

HAPPY NEW YEAR everyone! 

Don't party too wild, and if you do, drink your green tea before the binge - this is (contrary to the historical advice in the box above) indicated by the latest science you should remember from Thursday's Science Round Up on Super Human Radio ;-)

References:
    • Borges Bastos CL, Miranda H, Gomes de Souza Vale R, de Nazaré Dias Portal M, Gomes TM, da Silva Novaes J, Winchester JB. Chronic Effect Of Static Stretching On Strength Performance And Basal Serum Igf-1 Levels. J Strength Cond Res. 2012 Dec 18.
    • Ho SS, Dhaliwal SS, Hills AP, Pal S. Effects of Chronic Exercise Training on Inflammatory Markers in Australian Overweight and Obese Individuals in a Randomized Controlled Trial. Inflammation. 2012 Dec 19.
    • Morikawa Y, Mizuno Y, Harada E, Katoh D, Kashiwagi Y, Morita S, Yoshimura M, Uemura S, Saito Y, Yasue H. Aerobic interval exercise training in the afternoon reduces attacks of coronary spastic angina in conjunction with improvement in endothelial function, oxidative stress, and inflammation. Coron Artery Dis. 2012 Dec 14.
    • Neal CM, Hunter AM, Brennan L, O'Sullivan A, Hamilton DL, De Vito G, Galloway SD. Six Weeks Of A Polarised Training Intensity Distribution Leads To Greater Physiological And Performance Adaptations Than A Threshold Model In Trained Cyclists. J Appl Physiol. 2012 Dec 20.
    • Taylor C, Bartlett JD, van de Graaf CS, Louhelainen J, Coyne V, Iqbal Z, Maclaren DP, Gregson W, Close GL, Morton JP. Protein ingestion does not impair exercise-induced AMPK signalling when in a glycogen-depleted state: implications for train-low compete-high. Eur J Appl Physiol. 2012 Dec 23.

    Happy New Year Hangover Cures - 8 Cures That Work + Two Dozen Purported "Cures" That Have No Scientific Backup

    Happy New Year! In case this guy looks anywhere similar to how you feel after yesterday's party night, today's SuppVersity article is for you!
    "Happy New Year", health, love, ... you know the whole litany, so let's get over it and straight to the things that are really important, today. The hangover cures. In the following I have compiled an extensive yet probably by no means complete list of scientifically proven hangover cures that may help better than aspirin and plenty of water (Harvard Health Letter. 2006), alone.

    Apropos aspirin, it's actually not too bad to start with 400-800mg of it, if you are having a hangover. It has after been shown to block the increased prostaglandin synthesis in response to alcohol ingestion and thus counter at least the inflammatory aspect of the hangover (George. 1979).
    Better consume protein than alcohol learn why at the SuppVersity

    Alcohol Hampers Muscle Gains!?

    Sex, drugs... no good for athletes?

    Red Wine Lowers LDL / HDL Ratio

    Alcohol and Binge Eating

    Non-alc. Beer = Sports Beverage

    Alcohol May Trigger Gyno
    The latter cannot be said of another common pain killer: Acetaminophen, which failed to inhibit ethanol-induced subjective effects in human volunteers in a 1992 study by Pickworth et al. The same study by George et al. would yet also suggest that aspirin may also prolong the time it takes for the alcohol to leave your system completely... and this may not be your only problem, because the coingestion of aspirin and alcohol has been associated with an increased risk of gastrointestinal haemorrhage (Needham. 1971).

    So what do you do if water and aspirin are not enough? Well, here are a couple of suggestions - in a more or less random order, since there are hardly any studies that compare the efficacy of one to another.
    • Figure 1: Effects of 200mg tolfenamic acid on hangover symptoms in man (Kaivola. 1983).
      Tolfenamic acid - Tolfenamic acid is a very specific prostaglandin biosynthesis inhibitor that lead to significant reductions in hangover symptoms in a 1983 study by Kaivola, et al. (see Figure 1).

      The only problem is: The subjects consumed the 200mg of the anti-migraine drug tolfenamic acid before they started binge drinking. Whether the effects are similarly pronounced if you take it the day after remains to be elucidated.
    • Gamma linoleic acid (GLA) - The omega-6 fatty acid from vegetable oils like rapeseed/canola oil and soy beans, walnuts, flax seed (linseed oil), perilla, chia, and hemp seed effectively reduced the hangover symptoms of human volunteers in a study the results of which have unfortunately never been officially published (Moesgaard; based on Pittler. 2005).

      In view of the fact that I have only 2nd hand access to the results I cannot tell you how much GLA you would need. Considering the effect that the supplement contained B officinalis aka Borage, which contains 26-36% GLA, if it's not specifically enriched, I would yet assume that 100-300mg should do.
    Figure 2: Symptoms and possible contributers of hangover (Swift. 1998).
    • Yeast + B-Vitamins: Another trial tested the efficacy of 250 mg dried yeast, 0.5 mg thiamine nitrate, 0.5 mg pyridoxine hydrochloride, and 0.5 mg riboflavin in participants who consumed vodka (40% volume alcohol) amounting to a total of 100 g absolute alcohol (Laas. 1999). The difference in the change for the symptoms discomfort, restlessness, and impatience was statistically significant in favor of the yeast preparation and appear to suggest that the corresponding supplement aka "Morning Fit" works.

      Moreover, corresponding research from the Chungnam National University in Korea shows that a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts constitutes a  "a promising candidate for improvements of alcoholic hangover" (Lee. 2009), as well.
    • Oh!K - A hangover cure with green ginger, turmeric, pepper, and green tea extract, along with salt, citric and ascorbic acid and fructose as the carrier worked pretty well in a recent study by Gopi et al. (2014).
    • Sprite! Or rather a sprite-like herbal drink - In the media you may have read about Sprite, when in fact the two drinks researchers from the Sun Yat-Sen University in China tested and found to be effective in increasing the production of the enzyme that helps our bodies to get rid of alcohol were xue bi, a fizzy lemon and lime drink of which the researchers did not declare that it was indeed Sprite and hui yi su da shui, probably a type of soda water (Li. 2014).
    • After Affect(R): Another commercially available anti-hangover cure "proved" to be effective in a non-randomized non-controlled trial from the Utrecht University (Vester. 2012).
      Table 1: Rationale for the ingredients included in After-Effect©. 1 - Total dose of 5 capsules. 2 - Only those symptoms that showed a significant improvement during alcohol hangover are listed. GLA: gamma-linolenic acid, EPA: eicosapentaenoic acid (EPA), and DHA: docosahexaenoic acid (Verster. 2012).
      If it were not for the reasonable ingredient profile (see Table 1), I probably wouldn't have listed it, but with GLA, magnesium, B-vitamins & co it does contain a bunch of ingredients that may actually help.
    • Party Smart (carbonate mix) - Yet another commercial preparation that contains calcium carbonate (615 mg) and vegetable carbon (345 mg) and has - unfortunately - to be consumed while you are drinking.

      More specifically, the subjects in the 2004 study by Manu et al. consumed their first serving of two caplets with first drink and two more caplets every 2 to 3 hours (or 5 to 6 drinks).
      Figure 3: Mean hangover score and mean blood alcohol 10h after drinking (Manu. 2004).
      The data in Figure 3 does yet indicate that this alkalization regimen worked pretty well (I wonder if sodium bicarbonate would to the same ;-) is a pretty effective means to (a) keep the hangover in check and (b) help your body clear the alcohol from your bloodstream.
    • Aging! Ok, I know this does not really help you today, but maybe on New Year's Eve 2065! Tolstrup et al. found that hangover following engagement in binge drinking is much more common in the young than in the older age groups (Tolstrup. 2014). For women, similar results were obtained.

      As the scientists point out, "[t]his finding could not be explained by the usual amount of alcohol consumption, frequency of binge drinking, or the proportion of alcohol consumed with meals" (Tolstrup. 2014).
    List of anti-hangover remedies from the Internet - all w/out scientific evidence that they work (Pittler. 2004).
    You still feel like dying? If all these cures didn't help and you feel as if you were about to die, today, you may have inherited a special gene variant from of Aldehyde Dehydrogenase (ALDH2) an Asian ancestor that makes you extra susceptible to more severe hangovers (Wall. 2000).

    And if you are totally desperate you may want to give C scolymus aka Artichoke leaves and O ficus-indica extracts a final try. While two randomized controlled trials did not intergroup differences for their main outcome measures (Pittler. 2003; Wiese. 2004), both are often hailed as natural hangover remedies. The same can be said of most of the other remedies you will find if you google anti-hangover cures on the Internet (see table on the right). As Pittler et al. highlight in their 2005 review of the literature, none of them has reliable scientific evidence that would confirm that they are working | Comment on Facebook!
    References:
    • George, Frank R., and Allan C. Collins. "Prostaglandin synthetase inhibitors antagonize the depressant effects of ethanol." Pharmacology Biochemistry and Behavior 10.6 (1979): 865-869.
    • Gopi, Sreeraj, et al. "Studies on the effectiveness, safety and tolerability of two doses of Anti Hangover Drink in Reducing Alcohol Induced Hangover Symptoms in Adult Male Social Drinkers." Int.J.Cur.Res.Aca.Rev. 2.8 (2014): 125-131.
    • Harvard Health Letter. How to handle a hangover: drinking fluids may help with the morning-after misery from getting drunk. Harvard Health Letter 31.3(2006):3. 
    • Kaivola, S., et al. "Hangover headache and prostaglandins: prophylactic treatment with tolfenamic acid." Cephalalgia 3.1 (1983): 31-36. 
    • Laas I. A double-blind placebo-controlled study on the effects of Morning Fit on hangover symptoms after a high level of alcohol consumption in healthy volunteers. J Clin Res 1999;2: 9-15. 
    • Lee, Heon-Sik, et al. "Effects of a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts on ethanol hangover." Journal of medicinal food 12.6 (2009): 1359-1367.
    • Li, Sha, et al. "Effects of herbal infusions, tea and carbonated beverages on alcohol dehydrogenase and aldehyde dehydrogenase activity." Food & function 5.1 (2014): 42-49. 
    • Manu, M. B., and S. A. Kolhapure. "Evaluation of the Efficacy and Safety of “PartySmart” in the Prevention of Alcohol-induced Hangover: A Prospective, Randomized, Double Blind, Comparative, Phase III Clinical Trial." INDIAN JOURNAL OF CLINICAL PRACTICE 15.7 (2004).
    • Moesgaard S, Hansen NV. GLA effectively reduces hangovers. Pharma Nord Research, unpublished report. 
    • Needham, C. D., et al. "Aspirin and alcohol in gastrointestinal haemorrhage." Gut 12.10 (1971): 819-821. 
    • Pickworth, Wallace B., et al. "Acetaminophen fails to inhibit ethanol-induced subjective effects in human volunteers." Pharmacology Biochemistry and Behavior 41.1 (1992): 189-194.
    • Pittler, Max H., et al. "Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial." Canadian Medical Association Journal 169.12 (2003): 1269-1273.
    • Pittler, Max H., Joris C. Verster, and Edzard Ernst. "Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials." Bmj 331.7531 (2005): 1515-1518.
    • Swift, Robert, and Dena Davidson. "Alcohol hangover." Alcohol Health Res World 22 (1998): 54-60. 
    • Tolstrup, J. S., Stephens, R. and Grønbæk, M. (2014), Does the Severity of Hangovers Decline with Age? Survey of the Incidence of Hangover in Different Age Groups. Alcoholism: Clinical and Experimental Research, 38: 466–470. doi: 10.1111/acer.12238.
    • Verster, J. C., and O. Berthélemy. "Consumer Satisfaction and Efficacy of the Hangover Cure After-Effect©." Advances in preventive medicine 2012 (2012).
    • Wall, Tamara L., et al. "Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene." Journal of Studies on Alcohol and Drugs 61.1 (2000): 13.