.

.
marylin monroe
Showing posts with label eccentric. Show all posts
Showing posts with label eccentric. Show all posts

D-Finitively Relevant News: Vitamin D Supplementation Speeds Up Strength Recovery and Lowers Markers of Muscle Damage in Vitamin D-Sufficient Young Subjects

If we were all training at "Muscle Beach", we would probably not need any vitamin D3 caps to get our 25(OH)D levels into the recovery friendly 50ng/ml zone. They would already be there!
Ok, I know this looks odd, but it's really total coincidence that all the interesting vitamin D research is published in the last weeks of the year. Unlike the latest vitamin D articles, i.e.
  • "Vitamin D Builds Muscle: 70% Reduction in Myostatin, 45% Increase in Myotube Size in 10 Days" |  learn more
  • "Leucine, Insulin & Vitamin D*: A Hypertrophy Boosting Triplet That Does Not Make It From the Dish to the Gym?" | read more
today's SuppVersity article does yet leave little room for speculations about it's real-world significance. I mean, how could it, if the paper it discusses is titled "Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise" (Barker. 2013).
You can learn more about vitamin D at the SuppVersity

Vitamin D Builds Muscle

Leucine, Insulin & Vitamin D

Vitamin D = Fat Synthesizer

Overlooked D-Sources

Vitamin D For Athletes!

Vitamin D Helps Store Fat
The title does yet not "say it all". Moreover, what it doesn't tell you is the most important piece of information. The study period was short (35 days) the dose of vitamin D was relatively high (4,000IU) was conducted with "reportedly healthy and modestly active (30 minute of continuous physical activity at least 3 time/week) adult men with low, albeit normal vitamin D levels (25(OH)D ~ 30ng/ml)! The otherwise almost obligatory question about the potential relevance in "normal" human beings does thus become superfluous - and this is true for all the observations the scientists made, i.e.
  • ... the linear relationship between baseline 25(OH)D levels and the increase in serum vitamin D in response to the with an up to 150% increase in subjects in the deficiency zone and less than 50% increases in subjects in the >40ng/ml range, ...
  • ... the steady serum calcium levels, which make concerns about potentially kidney damaging increases in calcium from vitamin D3 supplementation obsolete, ...
... and, not to forget, the enhanced recovery in peak isometric force the researchers observed in their subjects after these had performed 10 sets of 10 repetitive eccentric-concentric jumps with a load of 75% of their respective body mass on their shoulders and a 20 sec rest period between each set.

For the researchers this is a model of a "muscle damaging event" (P< 0.05; ≈8% at 24-h), which was, as it was to be expected, associated with an increase in the circulating levels of the "liver enzymes"  alanine (ALT) and aspartate (AST) aminotransferase, of which many medical textbook will tell incorrectly tell you that they would indicate a strain on the liver / liver damage, when they are actually only markers of increase amino acid catabolism. The attenuation (P< 0.05) of the immediate and delayed (48-h, 72-h, or 168-h) increase in these enzymes in the vitamin D supplemented group  is thus an indicator of "muscle protective" or at least general protein sparing effects of supplementally increased vitamin D levels.
Figure 1: Strength recovery (%) from immediately post to 24 post workout, left; serum ALT values immediately after, 24h, 72h, and 168h after the exercise test (Barker. 2013).
The fact that the alleged decrease in muscle damage did not correlate with a decrease in muscle soreness does or doesn't negate the purported muscle protective effects of vitamin D. There is, as you should remember from Alex' excellent articles about DOMS, after all no direct link between ALT, AST, muscle damage and delayed onset muscle soreness, aka DOMS (learn more about DOMS). What is clear, though is that there was no consistent trend in the subjective measures of muscle soreness in the study at hand, so that Barker et al. are right, when they state that "[s]upplemental vitamin D was ineffective at abrogating muscle soreness in the SSC leg" (Barker. 2013). If it's an improvement in pain you are looking for, you'd be better off with one of the techniques Alex' discussed in part I of his article series.
Figure 2: It looks boring, but the linear association between the subjects baseline levels and the change in 25(OH)D and the ceiling effect at ~50ng/ml are also important results of the study at hand (Barker. 2013).
Bottom line: I guess you can't have it all, so I would not mourn over the lack of effect on muscle soreness. I mean, come on (!), this is one out of thousand (literally!) vitamin D studies with real-world relevance for you and me. A study that confirms that getting your 25(OH)D levels into the 50ng/ml range can actually have small, but stat. significant beneficial effects on your exercise performance (without negative effects on calcium, btw).

Furthermore, the fact that this increase to the 50ng/ml+ was achieved in all subjects with "only" 4,000IU D3 within only 35 days and was directly associated to their respective baseline level is an intruiging result on its own (see Figure 2). It does after all provide you with a rough guideline of what you have to do if your next 25(OH)D blood test comes back way below the 50ng/ml margin.

Against that background, there is no reason to frown about the fact that we still don't really know what vitamin D actually does to elicit its ameliorative effects on the performance decline in response to potentially muscle damaging stretch-shortening contraction. This was beyond the scope of the study at hand and cannot be investigated in isolated muscle cells... much contrary to the previously reported anabolic effects in the Petri dish, by the way, which may be exciting, but more or less irrelevant, if we can't observe corresponding increases in muscle hypertrophy in the real world.
References:
  • Barker, T., Schneider, E. D., Dixon, B. M., Henriksen, V. T., & Weaver, L. K. (2013). Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise. Nutrition & Metabolism, 10(1), 69.

Stretch-Shortening Cycle Exercise Superior to Eccentric Exercises in the Elderly - Identical Size & Strength Gains, With a Functional Advantage for Stretch Shortening Ex.

A stretch-shortening cycle (SSC) is an active stretch (eccentric contraction) of a muscle followed by an immediate shortening (concentric contraction) of that same muscle - e.g. jump squats.
Sacropenia, i.e. the age-related loss of muscle mass is a huge problem in our society. A problem the consequences of which start to surface way before older men and women suffer from serious limitations in their mobility and their ability to master (no longer) ordinary everyday-life tasks.

The loss of muscle mass is after all associated with an ever-increasing risk of metabolic syndrome, i.e. obesity, diabetes, high blood lipids, etc. (Baumgartner. 2004; Kim. 2011) - in both, young and old individuals, as well.

In contrast to many pharma-funded which spends millions of dollar on "promising new drugs" (that's what they say) to solve the problem.
Learn more about building muscle at www.suppversity.com

Tri- or Multi-Set Training for Body Recomp.?

Alternating Squat & Blood Pressure - Productive?

Pre-Exhaustion Exhausts Your Growth Potential

Exercise not Intensity Variation for Max. Gains

Battle the Rope to Get Ripped & Strong

Study Indicates Cut the Volume Make the Gains!
Researchers like Márk Váczi and his colleagues from the University of Pécs have long recognized that the development "promising new drugs" holds much less promise that the optimization of exercise regimen that are targeted to prevent sacropenia. In their latest paper in Experimental Gerontology the researchers describe the results of an experiment that was conducted to compare the effects of exercise training using stretch-shortening (SSC) and eccentric contractions (ECC) on the mechanical function and size of the quadriceps muscle and hormonal adaptations in healthy old males (N=16; age: 60-70 year old).
Figure 1: The torque–time curves of a stretch-shortening cycle and an eccentric exercise training contraction highlight the main difference between SSC (short, ultra-intense) and ECC (long, medium intensity) knee extensions (Váczi. 2014)
In that, Vávzi et al used an experimental approach in which the total mechanical work was identical in the two training groups and hypothesized that mechanical, hormonal, and muscular adaptations would differ in response to SSC vs. ECC exercise (note: plyometric training harnesses the beneficial effects of SSC | learn more).

The exercise of choice was, as so often, the single-lateral knee extension. The subjects trained 2-3 times per week with 48h rest between two sessions (each between 9-11 am in the morning).
Benefit from SSC irrespective of your age after you've read the following SuppVersity Classic: "Building the Jack-of-All-Traits Legs Workout With Squats, Jump Squats and Body Weight Plyometrics? At Least for Physical Education Students that Seems to Work." | read more
"Subjects performed 4 sets of 8 to 14 repetitions of unilateral knee extensions with both legs, with 2 min of rest between sets. The exercising legs were alternated across sets. The training contractions in SSC and ECC groups were similar to the SSC and ECC test contractions. [...A] unique element of the training program was that the average mechanical work for a session was still similar in the two groups. This was achieved by manipulating the stretch-load in the SSC group. For example, if a subject in the ECC group improved mechanical work production due to adaptation to the training, the stretch-load was adjusted to match subject-pair's mechanical work in the SSC group." (Váczi. 2014)
If we take a look at the outcome of the work and volume matched training with stretch-shortening and eccentric leg extensions, we see the following differences and similarities, when comparing the two exercise regimen:
  • Figure 2: The hormonal response to the exercise regimen was more or less identical (Váczi. 2014)
    There was a significant group by period interaction for RTD30 [rate of torque development after 30ms] and RTD50 (p < 0.05), suggesting that the two groups responded differently to the training. 
  • There was no group by period by time interaction in any of the hormonal variables, suggesting similar re sponses to the two training regimens. There was a significant time main effect in testosterone (p = 0.010), suggesting that the two exercise bouts (before and after 10 weeks training) uniformly increased testosterone 15% from pre to IP, and then decreased 10% from IP to 5 min post-exercise. 
  • There was a time main effect for cortisol (p = 0.018), suggesting that the two exercise bouts uniformly increased cortisol 21% from pre to IP, and then further increased 6% to 5 min post-exercise. 
  • There was a time main effect for testosterone/cortisol ratio (p = 0.002), suggesting that the two exercise bouts uniformly decreased the ratio 17% from pre to 5 min post-exercise. 
Now, in view of the fact that the overall strength (MCV) and size gains (CSA) were identical, as well. It would seem as if both types of exercise were equally beneficial.
Figure 3: Changes in maximum voluntary contraction (MVC), rate of torque development after 30ms and 50ms and cross sectional area of the quadriceps muscle (CSA) after 10 weeks of training (Váczi. 2014)
If we look at the most important functional deficits in aging muscle, however, it becomes obvious that the ostensibly negligible increase in the rate of torque development at the beginning of the exercise could determine whether an older individual falls and breaks a bone or whether he or she manages to "catch him-/herself" in time.
Bottom line: Overall the study at hand underlines there is more than just one way to skin the cat. In that, small allegedly practically non-significant differences like the increased rate of torque development in the study at hand can - from time to time - have important real-world relevance.

Figure 4: Strength & size gains in young men in response to 8 wk of SSC exercise training
And even if you are not 60 years and older, you can benefits. In 2005, Malisoux et al. evaluated the contractile properties of chemically skinned single muscle fibers from the leg muscle of eight young men before and after 8 wk of maximal effort stretch-shortening cycle (SSC) exercise training and found that their maximal leg extensor muscle force, vertical jump performance and peak force were improved 12%, 13% and 15-19% (depending on muscle fiber type), respectively; and the single-fiber crosssectional area increased 23% in type I, 22% in type IIa, and 30% in the most growth prone type IIa/IIx fibers. Needless to say that this makes SSC exercises "an effective training approach to improve fiber force, contraction velocity, and therefore power." (Malisoux. 2005) | Comment on Facebook!
    References:
    • Baumgartner, Richard N., et al. "Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly." Obesity research 12.12 (2004): 1995-2004.
    • Kim, Tae Nyun, et al. "Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: the Korean Sarcopenic Obesity Study (KSOS)." Diabetes research and clinical practice 93.2 (2011): 285-291.
    • Malisoux, Laurent, et al. "Stretch-shortening cycle exercises: an effective training paradigm to enhance power output of human single muscle fibers." Journal of Applied Physiology 100.3 (2006): 771-779.

    Is Eccentric Training More Anabolic Than Hypertrophy or HIT Training? If We Go by mTOR, Akt & Other "Anabolic" Signalling Proteins, the Answer is Yes!

    Is eccentric training the long-thought shortcut to the body of your dreams?
    I have never been a fan of HIT training - at least not in its classic version of doing three to maximal 5 reps with extreme heavy weights. The recently publishes study by Schoenfeld et al. (I wrote about it here) did yet already suggest that volume-matched high(er) intensity training is at least as efficient in building strength and size as your classic 3x sets of 8-12 reps in the so-called hypertrophy range.

    From other studies, we know that eccentric exercises appear to have a pretty profound effect on the strength and hypertrophy response, as well - you have read that only less than a week ago in "Supramaximal Eccentrics (+38%) on Leg Presses & Calf Raises Pay Off in Form of Extra Strength and Significantly Higher Lean Mass Gains of the Trained Muscles" (read more).

    The question is thus: Are high intensity and eccentric training viable alternatives to the classic 3x sets of 10x reps training protocols? And how do they compare to all-or nothing high intensity training to absolute failure?
    Learn more about the best muscle builders at the SuppVersity

    Optimizing Rest for Size and Strength Gains

    Alternating Squat & BP - Productive?

    Farmer's Walk or Squat? Is Strong- men T. For You?

    Full ROM ➯ Full Gains - Form Counts!

    Battle the Rope to Get Ripped & Strong

    Eccentrics Pay Off in Terms of Mass & Strength
    A group of German researchers from the German Sport University Cologne wanted to know what the signal protein response to the different training regimen would be and recruited a group of twenty-two healthy male sport students (age 24±6 years, height 181±9 cm and weight 79±2 kg) who hat to perform 70° (ROM) leg extensions, which were chosen as a reference exercise, in hypertrophy (HT), high intensity (HIT) and eccentric training (ECC) fashion:
    • HT: Three sets of ten unilateral concentric and eccentric leg extensions with 3-min rest between sets and 75 % of maximum eccentric and concentric force. Movement speed 65°/s with 66 s TUT
    • HIT: One single set of twenty unilateral concentric and eccentric leg extensions with the highest possible force generation in every contraction. Movement speed 40°/s with 70 s TUT.
    • ECC: Three sets of eight unilateral maximum eccentric leg extensions with 3-min rest between sets and 100 % maximum eccentric force in each repetition. Movement speed 25°/s with 67.2 s TUT.
    All subjects of the HIT and ECC group were verbally encouraged during the exercise session to perform all contractions in RE modes with maximum voluntary force. A visual feedback of their 100 % force reference curve was shown on a screen for further encouragement during each contraction. For subjects of the SD group, concentric and eccentric power was set to 75 % of their determined 100 % curve.
    Keep in mind: This is an acute study that won't tell you what will happen if you train eccentrically and like a madman during all of your training sessions - let alone on a 5x / week high volume schedule. In that case, overtraining may soon shut all anabolism down.
    An analysis of the blood samples that were taken before, as well as 15, 30, 60, 240 min and 24 h after the individual trials, the scientists sought to investigate the acute cellular impact of distinct RE modes via essential signalling measures.
    Figure 1: pmTOR and pAKT response to HT, HIT and ECC regimen (Gehlert. 2014)
    As you can see, the researchers' hypothesis, "that higher force generation and mechanical demands of skeletal muscle induce higher signalling responses than RE modes with lower force generation" (Gehlert. 2014) held, albeit only if you compare the mTOR and p-AKT response of the eccentric training protocol to the HT and HIT programs.
    "The phosphorylation levels of pFAK Tyr397, pJNK Thr183/Tyr185, pAKT Thr308/Ser473, pmTOR Ser2448, p4E-BP1 Thr37/46, p70s6k Thr389 / Ser421/Thr424 and pS6 Ser235/236 were significantly higher in ECC than those in STD and HIT at several time points (P < 0.01). pJNK Thr183/Tyr185 and pS6 Ser235/236 levels were significantly higher in type II myofibres in ECC compared with STD and HIT. HIT exerted throughout the weakest signalling response." (Gehlert. 2014)
    Based on these observations, the scientists conclude that  "high force development durin acute RE is superior for anabolic skeletal muscle signalling than fatiguing RE with lower force output but similar TUT" (Gehlert. 2014), which is a true statement, but one that ignores the discrepancy between anabolic signalling and effective muscle growth.
    Table 1: Results of meta-analyses of muscle mass gains in previous studies on concentric vs. eccentric training; con, concentric; CSA, cross-sectional area; ecc, eccentric - see bottom line for discussion (Roig. 2008)
    It is, for example true that the phosphorylation of p70s6k Ser421/424 and p70s6k Thr389 , p4E-BP1 Thr37/46 and pS6 Ser235/236 directly contributes to regulate protein synthesis, but this does not imply that the ECC exercise will in fact maximize protein synthesis, which is something the scientists didn't measure "[o]wing to technical limitations" (Gehlert. 2014) - major bummer!
    Figure 2: The increased strain during the eccentric workouts (see force production, bottom) comes at the cost of significantly increased muscle damage as signified by the elevated creatine kinase levels (learn more) 24h post workout (top; Gehlert. 2014).
    Bottom line: I would be cautious about granting the results of the study at hand too much weight. If you look at one of the few studies comparing the results of different trials, you will yet find that eccentric training...
    • is more effective at increasing total and eccentric strength than concentric training
    • appears to be more effective at increasing muscle mass than concentric training
    Interestingly, Roig et al. explain these findings much like Gehlert et al. by refering to the "higher forces developed during this type of exercise" (Roig. 2008). In that, they highlight that the adaptations after eccentric training are highly specific to the velocity and type of contraction and thus try to explain the discrepancies between various studies.

    If you asked me, the increased muscle damage and the corresponding need for longer recovery times may still render the "eccentric advantage" void - I'm not saying it may not be worth a try, but certainly warning you not to train like this 5x per week.
    Reference:
    • Gehlert, Sebastian, et al. "High force development augments skeletal muscle signalling in resistance exercise modes equalized for time under tension." Pflügers Archiv-European Journal of Physiology (2014): 1-14.
    • Roig, Marc, et al. "The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analyses." British journal of sports medicine (2008).

    Supramaximal Eccentrics (+38%) on Leg Presses & Calf Raises Pay Off in Form of Extra Strength and Significantly Higher Lean Mass Gains of the Trained Muscles

    It goes without saying that you need someone to help you to do eccentric leg presses... well, unless you use one leg to help with the concentric part of the exercise, obviously.
    Training techniques have long been heralded as the single best way to increase your gains. These days, however, the discussion on bodybuilding and fitness boards has evolved away from talking about drop sets, singles, staggering and forced reps and towards BCAAs, whey, herbs and antioxidants - in short: People believe they could buy results, they would otherwise have to work for.

    Apropos work, the amount of work the subjects in a recent study from the JES Tech, Ilc., Wyle Science and the NASA Johnson Space Center in Houston had to perform was not even overtly demanding.
    Learn more about the best muscle builders at the SuppVersity

    Optimizing Rest for Size and Strength Gains

    Alternating Squat & BP - Productive?

    Farmer's Walk or Squat? Is Strong- men T. For You?

    Full ROM ➯ Full Gains - Form Counts!

    Battle the Rope to Get Ripped & Strong

    Up Your Squat by 25% With Sodium Bicarbonate
    The study, which was conducted by Kirk L. English, James A. Loehr, Stuart M. C. Lee,
    Scott M. Smith and published in the European Journal of Physiology, required the 40 male subjects (34.9  ±  7  years, 80.9  ±  9.8  kg, 178.2 ± 7.1 cm; mean ± SD), who were  free from any orthopedic or other medical conditions, but had not participated in a strength training program for at least 6 months prior to entering the study (only five subjects had any history of strength training), performed a supine leg press and calf press training program 3 days per week for a total study duration of 8 weeks. 
    Table 1:  Warm-up and training volume and concentric training intensity (% pre-training 1-rM) during 8 weeks of resistance exercise (Smith. 2014); (a)  the number of warm-up and training sets × repetitions performed was the same for all 3 days of each training week; (b) Warm-up intensity (not shown) progressed in a graded fashion from 50 % 1-rM to the prescribed training intensity (e.g., week 1 high intesity day: warm-up at 50 and 60 % followed by training sets at 64 % 1-rM). Warm-up repetitions decreased with each successive set as intensity increased (e.g., week 8 high intensity day: 8, 6, 6, and 4 repetitions at 50, 64, 73, and 82 % 1-rM, respectively, followed by training sets at 96 %1-rM); (c) rest periods between sets were 1 min (50–70 % 1-rM), 1.5 min (70–80 % 1-rM), 2 min (80–90 % 1-rM), and 2–3 min (90–100 % 1-rM)
    The subjects were matched for pre-training leg press (1-rM) and randomly assigned to one of five training groups. concentric training load (% 1-rM) was constant across groups, but within groups, eccentric load was 0, 33, 66, 100, or 138 % of concentric load.  Muscle mass (dual energy X-ray absorptiometry; DXA), strength (1-rM), and BMD (DXA) were measured pre- and post-training. Markers of bone metabolism were assessed pre-, mid- and post-training.

    The idea was to analyze the adaptive responses to a uniquely broad range of eccentric to concentric loading "to inform the development of appropriate exercise prescriptions for a range of populations and to guide resistance exercise hardware requirements for exploration spaceflight." (Smith. 2014)... needless to say that you don't have to be an astronaut to benefit from Smith's findings.
    Figure 1: Individual and mean (±SE) leg press (left) and calf press (right) strength before and after  8 weeks of training. Asterisk significant difference from pre-  to post-training (P < 0.05); hash significantly different from 0,  33, and 66 % training groups (Smith. 2014)
    As you can see in Figure 1, the increase in leg press 1-RM in the 138 % (highest resistance) group (20 ± 4 %) was significantly greater (P < 0.05) than the 0 % (8 ± 3 %), 33 % (8 ± 5 %) and 66 % (8 ± 4 %) groups.

    Compared to the 100 % group, on the other hand, using supramaximal weights did not yield a statistically significant advantage (13 ± 6 %; P = 0.15). Still, while all groups, except the 0 % group, increased their 1-RMs (P < 0.05) on the calf press, only the supramaximal training elicited statistically significant leg lean mass gains! So, even if there was only a non-significant strength advantage we are still dealing with an intriguing "mass advantage" of supramaximal eccentrics - an observation that could refuel the debate about the role of muscle damage as a trigger of skeletal muscle hypertrophy.
    Figure 2: Changes in body composition, i.e. total body mass, lean mass and leg lean mass, sign. increases only in the 138% group (Smith. 2014)
    Bottom line: Statistics inform us that strength-wise (only!) it wouldn't be necessary to use supramaximal weights on the eccentric part of an exercise. Common sense and the exclusive increase in lean leg mass in the 138% group, on the other hand, indicate that it would very well make sense to have a partner assist you during the concentric phase of your leg workouts, in order to torture your self on the eccentric portion. The results, a statistically significant lean mass and a visible strength advantage are unquestionably worth it and certainly more pronounced than the effects of many of the dubious supplements people prefer to talk about on the fitness and bodybuilding boards all over the Internet, these days (discuss the results on Facebook).
    References:
    • Smith et al. "Early‑phase musculoskeletal adaptations to different levels of eccentric resistance after 8 weeks of lower body training." European Journal of Physiology (2014). Accepted Manuscript.

    Fast & Slow, Heavy & Light, Eccentric & Concentric: Do All These Fancy Training Variables Really Matter? Probably For Power. Not So Much for Size, Though.

    Image 1: According to Sakamoto, 2011, EMG
    activation during the bench press increases
    with rep-speed & weight (pic from mylot.com)
    "Go heavy or go home!" You probably have heard this advice time and again and, after all, two recent studies appear to suggest that, when all is set and done, ah... I mean all sets are done, the thing your muscles seem to care most about is workload. While the study by More et al. (Moore. 2011) does not tell us anything about the effectiveness of training with different rep speeds, it goes to show that concentric and eccentric training are similarly effective, when it comes to building sleeve bursting biceps. Sakamoto et al. (Sakamato. 2011), on the other hand, found that EMG activity of the pectoralis major increases with rep speed and (readers of the SuppVersity EMG Series know that already) weight. Now, before we jump to any preliminary conclusions, let's tackle the studies in some more detail...

    The nine healthy, but previously not weight-training average Joes (mean age: 22yr; height: 1.75m; weight:78.3kg) from the Moore study (Moor. 2011) performed single arm biceps curls on a dynamometer twice per week. The volume increased from week one to week five from 2 to 6 sets and was cut back again in the last (ninth) week before the final testing session. Other than in similar studies on the effectiveness of eccentric vs. concentric training, the subjects did not perform their dynamometer curls either concentrically or eccentrically, but were instructed to perform concentric curls with one arm and eccentric curls with the other. Right and left arm had previously been randomly assigned to either the maximal lengthening (eccentric) or shortening (concentric) condition, so that limb dominance (n=5 dominant; n=4 non-dominant) was adequately counterbalanced. Moreover, the subjects had to perform ~40% more repetitions on the concentrically trained arm, to ensure total work was equal, or, put differently, to make up for the greater muscle force generation (+60% total work per repetition in eccentric vs. concentric) during eccentric dynamometer curls. Thusly, the participants performed the same 51.8MJ of work with each of their arms in the course of the 9-week training program.

    Under these equalizing conditions, workoutput for both conditions rose similarly over the 9-week training program:
    Total work per repetition increased from week 1 to week 9 for both LC and SC (main effect for time, P = 0.001) with no difference between conditions (time by condition interaction, P = 0.63). The average increase in work per repetition was similar between LC and SC (17.2 ± 6.3 vs. 22.1 ± 8.9%, respectively; P = 0.69). There were increases (at least P<0.05) in peak torque for all velocities tested (*8–20%) with no significant difference between conditions.
    The scientists also found similar results for the muscle crossectional area (CSA), which had been "virtually identical (P = 0.99) before training" (48.5mm² vs. 48.4mm², for the ecc. and con. trained arm) and "increased similarly between conditions" (ecc. 6.5 ± 0.6% vs. con. 4.6 ± 0.4%, respectively; interaction, P = 0.37). What may initially sound like one of those statistically induced geeky underestimations of real world effects, i.e. calling 6.5% vs. 4.6% increases in muscle CSA "similar", turns out to be actually negligible if you calculate the respective absolute difference in CSA increase which is less than 1mm², or an area with the size of a pinhead.
    Figure 1: Other than total work per repetition, the respective peak torque development did vary significantly (+8.9% vs. +13.5% for con vs. ecc) between the concentrically and the eccentrically trained arm (data adapted from Moor. 2011)
    If, however, you plot the peak torque data from table 1 from the Moore study (I did that for you in figure 1), you will realize that, after all, there is more of a difference between the two training regimens than Moore and his colleagues dissertations would make you think. In fact, their assertion that "there was a main effect for condition for peak torque measured at 0.79 rad/s [slow concentric] in that LC [eccentrical training] was *8% greater than SC [concentric training]" is simply not consistent with the data they provide.
    Note: A comment by "anoymous" (guys give me at least a pseudonym!) reminded me that in yesterday's hurry I forgot to mention a major caveat to the study. The latter is directly related to the unilateral training protocol which could potentially (or rather certainly) lead to cross-over effects from one arm (probably the eccentrically trained one) to the other. Similar effects have been observed in e.g. Adamson et al., 2008, where rate of force development and maximal isometric contraction (37% vs. 35%) in 10 adult females increased similarly in both arms, although the ladies had trained only one arm. It is yet notable that the 1RM increased almost exclusively in the trained arm and that the strength increases in the Adamson study occurred in the absence of muscular hypertrophy and are thus attributed by the authors to neurological addaptions of which obviously both arms benefited to a similar degree.
    As far as peak torques are concerned the available data (with reservations that the data the authors provide in table 1 of their paper is correct) would suggest that the peak torque increments in the concentrically trained arm for different repetition tempos were on average 4.6% greater than those for the eccentrically trained arm, or, in other words, the higher rep lower weight concentric training resulted in greater strength improvements than the higher weight, lower rep eccentric training, which is so contrary to what you see in similar studies that I would assume that the authors just got the captions wrong and the data in figure 1 would have been reversed, i.e. what now is red should be blue and what now is blue should be red... but who cares, anyway? Focus on getting a good contraction on both the con- and the eccentric phase of your curls, do the exercises described in the SuppVersity EMG series and grow ;-)!
    Figure 2: The time [in s] to "speed failure" (i.e. not being able to complete another rep at the given tempo / slow: 5.6s; medium: 2.8s; fast: 1.9s) increases with increasing tempo and load expressed in % of 1 repetition max, 1RM (data adapted from Sakamato. 2011)
    Fortunately, the Sakamato study does not contain similarly confusing results. In essence the study, which investigated muscle activations under varying speeds and intensities during bench press using surface electromyography (EMG) found that in the 13 weight-trained men (21.7 ± 3.6-year-old) who performed bench press until fatigue under five intensities (40–80% 1RM), and four speeds (slow 5.6-s/repetition, medium 2.8-s/repetition, fast 1.9-s/repetition, and ballistic maximum speed), found that ...
    ...faster conditions [...] produced a significant fall in amplitude during the final concentric phase compared to slower movements [while at the same time] after fatigue, EMG amplitude increased, with the speed effect being maintained. 
    This means that in the rested state at the beginning of the training you still have the explosiveness to really "pump" the weight up and thus pump out more reps. On the othrt hand, maximum muscle stimulation does not occur before your pectoralis major brgins to fatigue later in the exercise session (cf. figure 3).
    Figure 3: Normalized EMG activity at five time points for a given rep tempo / slow: 5.6s; medium: 2.8s; fast: 1.9s / in the rested and fatigued state (data adapted from Sakamato. 2011)
    According to the EMG data in figure 3, it does make sense to start (after an appropriate warm up) with heavy and explosive sets / movements and to switch to medium weights and tempo later in a training session. But wait, isn't that exactly what generations of successful trainees have been doing already? Well, I guess this is then another case, where practical training experience beat exercise science by decades and thus further evidence that much more than in the case of nutrition & supplements most of the research that is put into specific exercise programs does little more than reproduce pieces of the knowledge that has accumulated in the heads of trainers and trainees all around the globe ever since the earliest days of physical culture.

    Fast Paced High-Resistant Explosive Circuit Training Burns More Fat and Builds More Muscle Than Classical Weight Training. Trainees Dropped 1.5% Body Fat and Gained 3 Pounds of Lean Mass in 8 Weeks.

    Figure 1: Outline of the HRC protocol
    used by in the study.
    The beneficial effects of fast-paced (indicating short / no rest periods between exercises) circuit training on fat loss have long been established. With the original intention being the addition of an aerobic component to traditional strength training routines, the loads (weights) that are usually used in these types of exercise regimens are often to low to elicit significant strength or muscle gains. This, however, was different in the study protocol Pedro E. Alcaraz and his collegues from Spain and Australia used in their most recent study (Alcarez. 2011).

    Alcarez et al. recruited 33 healthy men, who "had been regularly performing resistance training (RT) in a gymnasium (e.g., ca. 6–12 repetitions per set, 3 sets per exercise, 2–4 d/week" (in other words recreational weight lifters) and assigned them to one of two training regimens:
    • High resistance circuit training (HRC): 2x 3-6 circuits à three exercises with 5 minutes rest between circuit I and circuit II. There was a bi-weekly progression from 1 to 2 to 3 rounds on each of the two circuits. This means that in their 3 workouts per week (at least one rest-day in-between) the subjects performed 18-36 sets per workout of 6 repetitions at 85%-90% of their individual 1RMmax [1RMmax = maximal weight a person can perform a single repetition with adequate form with] with roughly 35 seconds 'rest' between exercises (this was the time it took them to move from one exercise to the next). Notwithstanding the high workload, each of these workouts took them only 55min-78min to complete.
    • Traditional strength training (TS): For the same exercises that were used in circuit I and II in the HRC group (cf. figure 1), the subjects in the TS group performed 2x warm-up sets at 10 and 8 repetitions of the 6% max (1 minute rest in-between) followed by 3 sets of 6 repetitions at 85%-90% of their individual 1RMmax. Due to the one minute rest between individual sets, as well as the 5-minute pause in between exercises 1-3 and exercises 4-6, the supervised workouts of the TS group were on average 125min long.
    One specifically important and oftentimes under-appreciated parameter, both groups had in common, was the lifting tempo:
    The eccentric phase of each exercise was performed for approximately 3 seconds, whereas the concentric phase was performed at maximum velocity. This sequence was standardized in the first training week and eccentric phase duration was regularly timed as feedback for the subjects.
    In that, what the subjects did was fundamentally different from what I am (unfortunately) forced to look at day in and day out in my gym: people just moving weights instead of training muscles for strength or hypertrophy. With an emphasis on the explosiveness of the concentric part (where push / pulling the weight) of the movement and an accentuation of the deceleration in the course of the 3 second eccentric part (where lowering of the weight) of the exercise, you do just that - you train your muscle for strength and hypertrophy. The data in figure 2 underlines that this strategy works, regardless of whether you stick to the classical strength training protocol with longer rest periods (TS) or if you innovate your training by integrating some explosive strength circles.
    Figure 2: Bench press concentric peak power [in W] increase measured for different loads (45%, 60% and 80% of 1RMmax) after 8 weeks on a traditional or a high resistance circuit training program (data adapted from Alcarez. 2011)
    Obviously the classical strength training, where the three sets of bench presses were performed one after another and with more than adequate rest of 3 minutes produced greater increases in peak bench press performance with the most significant advantages for the traditional training routine (TS) in the range of 60% of the individual one-repetition maximum (1RMmax). So, if you are all about strength and can afford to invest 120 minutes three times à week into your training and like what you have been doing, you can stick to what worked for generations of lifters. If, however, you still don't have your summer-six-pack ready, have only 60 minutes to train, or - as almost 90% of the gym-goers claim - "just want to look good naked", or even just try something new, you should give the explosive strength circuits a try.
    Figure 3: Changes in fat and lean body mass [in kg] after 8 weeks on a traditional vs. a high resistance circuit strength training protocol (data adapted from Alcarez. 2011)
    Although the advantages of high resistance circuit training over traditional strength training in terms of on body composition (cf. figure 3) appear to be less significant than those TS has over HRC in the strength department (cf. figure 2), the significance of the data must be relativized in view of the large standard deviations which are as high as ~70%-110% of the improvements of both strength and body composition.
    Note: I think I do not have to tell you, the educated readership of the SuppVersity, that it goes without saying that it is very likely (yet still warrants scientific validation) that high resistance circuit training will also produce better results in terms of body (re-)composition (less fat, more muscle) than cardio training (cf. Exercise! Beneficial Effects of Resistance Training on Variables of General Health) or dieting (cf. Calorie Restriction vs. Exercise for Optimal Body Composition?), alone.
    Consequently, the conclusions of the authors, that the gains in strength and body composition in the HCR group "are identical to those obtained with traditional, heavy strength training" is spot on: In the end, it is probably all about your personal training-philosophy, -style and -preference what will work better for you as an individual. One thing you should keep in mind though is to explode on the way up and slow down on the way down; or, in other words, Add high resistance circuit training to your repertoire, if you will, but don't forget: Train the muscle, don't just move the weight!

    Slow Down to Build Up? 4x Higher Growth Hormone After Slow (4s) Eccentric Biceps Curls, But What's It Worth?

    Fast or slow for eccentric biceps curls? Is that a question of faith or can science provide us with an adequate answer?
    "What the ****? Training slow is for pussies!" Ok, admittedly the subjects in the study today's SuppVersity article is going to deal with were ladies (obviously no pussies), but I do not need a study, to tell you that the "pussy" training can hurt significantly more than the "bro" version that usually ends in ballistic movements that are meant to impress the male and female "pussies" at the gym and will yield astonishing increases in trap-size from "bicep curls". Now, I am digressing from the topic at hand, which is: Does it just hurt or does it also work? What? Ah, yeah... I am talking about training at a slow velocity. Eccentric training to be specific. Exactly the kind of training researchers from the ), State University of Campinas have investigated in their latest experiment (Libardi. 2013).

    Fast or slow, what's the way to go?

    What did the workout look like? Subjects performed five sets of six maximal eccentric contractions of the elbows flexors with the non-dominant arm on an isokinetic dynamometer (Model 4; Biodex Medical Systems Inc.) at two different angular velocities, 30°/s (SV) and 210°/s (FV)  After each eccentric action, the lever arm of the isokinetic dynamometer returned passively to its original position, at the specific velocity of each group, that is, 30°/s for SV and 210°/s for FV (1:1 work-to-rest ratio). The rest interval between sets was 60 s for both groups.
    The intention of the scientists was to elucidate, whether there is an influence of the velocity at which previously untrained young women in their early 20s on the workout-induced systemic growth hormone, corstisol, free and testosterone response.  To shit ends the 17 subjects were randomly assigned to two groups
    • the slow velocity group (SV), which performed their machine biceps curls at a velocity of 30°/s
    • the fast velocity group (FV), which performed the identical exercise at a velovity of 210°/s and thus 7x faster
    The range of motion was from 125° to 5° of elbow flexion for both groups. The workouts were performed on an isokinetic dynamometer (Model 4; Biodex Medical Systems Inc., New York, NY, USA) at the given velocity. The decision to use eccentric exercises was taken based on previous results by Farthing & Chilibeck, which indicate that isolation exercises will yield greater adaptations such as higher muscle hypertrophy and muscle strength gains compared to concentric actions (Farthing. 2003).

    All participants were "encouraged" by the investigator equally, and "visual feedback was provided via Biodex monitor to maximize torque output for each repetition" (Libardi. 2013). Total work and mean peak torque developed in the eccentric exercise were recorded for further analysis and pre-and post.

    The slower you go the more you grow?

    The Blood samples (20 ml) which were drawn at baseline (Pre), immediately postexercise (IP), and 5, 15 and 30 min following the training session, would in fact suggest that the subheading "the slower you go, the more you grow" wasn't to way off the truth.
    Figure 1: Total work, mean peak torque and growth hormone levels immediately, 5 min, 15 min and 30 min after the workout; data expressed relative to arithmetric mean at the given timepoints (Libardi. 2013)
    After all, the only significant difference was the post-workout elevation in growth hormone, which was 3.7x, 4.1x and 3.5x higher immediately, 5 min and 15 min after the eccentric biceps curls.

    How did this come about? Well the data in figure 1 would suggest that it's neither the total workload or the peak power, but it does not take a physicist to tell that the way the "total workload" is measured has absolutely nothing to do with the associated physiological energy expenditure. "Way times force" may theoretically yield Newton meters and is as such often used as the unit of energy (un-)fortunately the human body is a little more complex than that and I do honestly not know of any way that can accurately calculate the energy expenditure during a workout based on standard equations like these. The same goes for the nondescript term "exercise intensity", so that both - a higher energy expenditure and higher "intensity" are both candidates that could explain the increase in GH (the former would by the way suggest that they are irrelevant for the growth response and and are mainly meant to tap into the energy stores to fuel the workout / post workout glycogen replenishment).



    So what does that mean, practically? Similar differences (or trends) were not observed for either free, or total testosterone or the corstiol response to the workout. This is yet not the only reason why the real world significance of the increase in the allegedly growth promoting eponymous hormone remain highly questionable.
    Figure 2: The real world speaks a different language - Biceps muscle CSA in young men before and after 8 weeks of fast or slow eccentric biceps training in a previous study (Shepstone. 2005)
    • Firstly, we still don't really know to which extend the immediate changes in the expression of theoretically growth promoting hormones in the vicinity of a workout can actually induce or at least promote the adaptive response to exercise. It may, for example, well be that there is a certain threshold level beyond which additional increases in GH, teststosterone & co don't make a significant difference.
    • And secondly, and more importantly, it is not impossible that the results would be very different for (a) a different group of subjects, (b) complete reps (=concentric + eccentric reps), (c) other muscle groups like classic "push" muscles as the pecs or the legs, etc. 
    Moroever, the results of practically relevant 8-week studies such as Shepstone et al. (2005; see figure 2) do actually speak a very different language and support those researchers who doubt the physiological relevance of improvements in the acute anabolic milieu after a workout.

    Suggested reads: 

    • The expression of local GH & IGF splice variants may be of much greater importance than their systemic values (read more)
      Does the testosterone and overall hormonal response to workouts even count, or are we still chasing a hormonal ghost? In the Short News from Saturday, March 2, 2013
    • IGF-1 and its Splice Variants MGF, IGF-IEa & Co - Master Regulators or a Bunch of Cogs in the Wheel of Muscle Hypertrophy?  In the Intermittent Thoughts in Dec. 2011 
    • Differences in Growth Hormone, Insulin and IGF-1 Response in Trained and Untrained Resistance Trainees - Further Evidence That GH Builds Neither Muscle Nor Strength (read more)



    References:
    • Farthing JP, Chilibeck PD. The effects of eccentric and concentric training at different velocities on muscle hypertrophy. Eur J Appl Physiol. 2003 Aug;89(6):578-86.
    • Libardi CA, Nogueira FR, Vechin FC, Conceição MS, Bonganha V, Chacon-Mikahil MP. Acute hormonal responses following different velocities of eccentric exercise. Clin Physiol Funct Imaging. 2013 May 15.
    • Shepstone TN, Tang JE, Dallaire S, Schuenke MD, Staron RS, Phillips SM. Short-term high- vs. low-velocity isokinetic lengthening training results in greater hypertrophy of the elbow flexors in young men. J Appl Physiol. 2005 May;98(5):1768-76.